Non-IgE mediated describes an allergic or hypersensitivity reaction that does not involve immunoglobulin E antibodies, the classic mediators of immediate allergy. Instead, these reactions run through T cells or other immune pathways, producing delayed symptoms that appear hours or days after exposure. In food allergy, the distinction matters clinically: non-IgE mediated conditions include food protein-induced enterocolitis syndrome (FPIES), allergic proctocolitis in infants, and coeliac-adjacent enteropathies, which present with vomiting, diarrhoea, or faltering growth rather than hives and anaphylaxis. Standard allergy tests measuring specific IgE or skin-prick responses come back negative, so diagnosis rests on clinical history and supervised food challenges. Dietary management still requires strict avoidance of the trigger food, commonly cow’s milk or soy in infants, with most children outgrowing the condition.