The National Institute for Health and Clinical Excellence, universally known as NICE, is an independent advisory body within the English and Welsh National Health Service that issues evidence-based guidance on clinical practice, public health, and social care. For food and nutrition professionals, its relevance lies in recommendations on weight management services, cardiovascular risk reduction, type 2 diabetes prevention, and the cost-effectiveness of nutrition interventions. NICE guidance is produced through systematic review of clinical and economic evidence by expert committees, and commissioners across the NHS generally treat it as the benchmark for funding decisions. Its technology appraisals on weight-loss medicines and surgical options also shape obesity treatment pathways.