A substance that, when consumed, produces intoxication: altered mental state, impaired coordination and judgement, and in larger doses poisoning. Alcoholic drinks are the most familiar intoxicants, acting as depressants on the central nervous system, but the term also covers certain drugs, solvents, and plant-derived compounds. The effects depend on dose, the individual’s tolerance and body size, and whether the substance is taken with food. Chronic use of intoxicants can damage the liver, brain, and other organs, and many carry risks of dependence. Food and drink regulations control the sale, labelling, and advertising of alcoholic intoxicants, setting legal limits for driving and minimum ages for purchase.