Cholinesterases

Cholinesterases are the enzymes that break down choline esters, chiefly acetylcholine, in nerves and blood, comprising true acetylcholinesterase (EC 3.1.1.7) at nerve synapses and pseudocholinesterase (EC 3.1.1.8) circulating in plasma. They matter in food safety because organophosphorus and carbamate pesticides inhibit them, and that inhibition is the mechanism of pesticide poisoning. Measuring cholinesterase inhibition is a standard tool in pesticide residue testing and in monitoring occupational exposure among farm workers. Keeping exposures low through label compliance and protective practices protects both consumers and applicators.